The goal of the strategic project is to provide research leadership, develop sovereign technologies, new training models and translate them into clinical practice.
Project Areas:
-
Diagostics. The design, development, testing and translation of advanced diagnostic radiopharmaceuticals, hybrid imaging systems, positron emission and single photon computed tomography facilities, smart data processing systems, clinical decision support systems, diagnostics and monitoring systems incl. instant diagnostic systems.
-
Therapy. The design, development, testing and translation of treatment and theranostic radiopharmaceuticals, methods and techniques to improve the quality and effectiveness of X-ray therapy, hardware and software and X-ray facilities, the development of binary technology based on the TPU unique research facilities.
-
Rehabilitation. The design, development, testing and translation of customizable implants, hardware and software for the neurorehabilitation of patients with circulatory system disorders, health technologies for the improvement of life quality and activity after diseases.
TPU R&D projects in biomedical and healthcare engineering:
Dr. Elena Stasyuk
Senior Research Fellow, Nuclear Reactor Laboratory No. 31
- Radiopharmaceuticals based on nano-sized aluminum, glucose compounds and other Tc99m-labeled molecules for accurate diagnostics of oncological diseases.
Prof. Viktor Pavlovsky
Kizhner Research Center, School of Advanced Manufacturing Technologies
- Synthesis, biological evaluation and molecular modeling of azacrown ether.
- Synthesis, affinity to benzodiazepine receptors, and pharmacological properties of 3-acyloxy-5-aryl-7-brom-1,2-dihydro-3H-1,4-enzodiazepines-2- one derivatives.
Prof. Viktor Filimonov
Kizhner Research Center, School of Advanced Manufacturing Technologies
- Novel biodegradable materials for smart implants.
- Experimental techniques for the separation and analysis of Galodif anticonvulsant entatiomeric forms.
Prof. Elena Krasnokutskaya
Kizhner Research Center, School of Advanced Manufacturing Technologies
- Novel techniques of heterocyclic compound synthesis and the development of advanced materials for medicine and engineering.
- Novel techniques and reagents of organic synthesis for the development of advanced pharmaceuticals and their targeted delivery.
Prof. Svetlana Buyakova
Materials Science Department, School of Advanced Manufacturing Technologies
- Porous ceramic osteoconductive materials for the osseous tissue replacement.
Prof. Sergey Panin
Materials Science Department, School of Advanced Manufacturing Technologies
- The development of design fundamentals incl. feedstocks, tribotesting, biocompatible wear-resistant polymer-polymer coupling based on thermoplastic matrixes of ultrahigh molecular weight polyethylene and polyetheretherketone to develop customizing joint implants using the additive technologies.
Dr. Vladimir Tolmachev
Director of Oncotheranostics Research Center
- The development and preclinical evaluation of radiolabeled biologically active compounds (antibodies, polysaccharides, proteins, peptides and small molecules) for biomedicine. The pioneering studies of framework engineering proteins in a radionuclide imaging and medicine are of prime importance:
- Labeling techniques using the following:
- positron-emitting radionuclide 18F;
- long-lived and unconventional positron-emitting radionuclides (44Sc, 68Ga; 55Co,64Cu, 110mIn, 76Br, 124I, 89Zr);
- single-photon emitters (111In, 123I, 99mTc);
- therapeutic radionuclides (131I; 114mIn, 90Y, 177Lu; 186Re, 188Re; 211At).
- Techniques of radionuclide production techniques for biomedicine:
- manufacturing of unconventional positron emitters 76Br, 110mIn, 68Ga, 66Ga, 83Sr, 124I, 61Cu, 72As, 45Ti, 89Zr, 86Y, 52Fe and 52Fe / 52Mn; 134Ce / 134La;
- manufacturing of 114m / 114In и 211At for radionuclide therapy.
- The molecular design and characterization of in vitro radiolabeled compounds.
- Pre-targeting techniques based on PNA-PNA interaction and the Diels-Alder reaction.
- Pharmacokinetic studies of labeled compounds with PET.
Prof. Roman Surmenev
Director of the Material Physics and Composite Materials Research Center
- Piezo- and magnetic-electric materials, biomedical composites.
- Core-shell nanoparticles for theranostics.
- Biopolymer-based piezonanogenerators, composite materials based on piezopolymers with ceramic and magnet nanoparticles.
- The additive printing of piezopolymer, ceramic materials and composites.
- The development, production and testing of piezopolymer biomedical models.
Prof. Mekhman Yusubov
Chief Research Fellow, Research School of Chemistry and Applied Biomedical Sciences
- The fundamentals of environmentally friendly technologies in fine organic and bioorganic synthesis using the polyvalent iodine compounds.
- Methods of the development diagnostic products based on fluorine and iodine organic compounds for nuclear medicine.
- The sustainable development of advanced pharmaceuticals, veterinary medicine and dietary food supplements for human and livestock animals.
- Effective methods for the rapid diagnostics of socially significant respiratory diseases using laser spectroscopy.
Dr. Antonio Di Martino
Research School of Chemistry and Applied Biomedical Sciences
Prof. Alexey Pestryakov
Research School of Chemistry and Applied Biomedical Sciences
Prof. Andrey Khlebnikov
Kizhner Research Center, School of Advanced Manufacturing Technologies
Dr. Maria Larkina
Senior Research Fellow, Oncotheranostics Research Center, Research School of Chemistry and Applied Biomedical Sciences
- Research of targeted radionuclide agents for molecular diagnostics of malignant tumors.
- In vitro and in vivo studies of radiopharmaceuticals, the development and research of radiosensitizing and radioprotective compounds, the evaluation of biological impacts on human cells and in vivo models, the study of biocompatibility of advanced materials, nanoparticles and 3D scaffolds, studies of cytotoxicity and bioactivity of new chemical compounds, candidate compounds and drugs in tumor and normal cells.
Prof. Oleg Khasanov
Materials Science Department, School of Advanced Manufacturing Technologies
Prof. Evgenia Sheremet
Research School of Chemistry and Applied Biomedical Sciences
- Smart clothes.
- Reduced graphene oxide-based composites for bioelectrodes.
Prof. Evgenia Sukhikh
Director of Research Technological Reference Center of Ionizing Radiation in Radiology, Radiation Therapy and Nuclear Medicine
Dr. Maria Surmeneva
Material Physics and Composite Materials Research Center
- Additive manufacturing technologies for implant materials, biomedical material engineering, biomedical metamaterials.
- The development and research of bioactive coating for metal-, ceramic-and composite-based implants.
Dr. Sergey Tverdokhlebov
Associate Professor, Weinberg Research Center
- Biostable and biodegradable polymer implants.
- Bioactive coating on implants used for the osteosynthesis and coating equipment.
- Hybrid coating materials for coronary stents for the atherosclerosis treatment and restenosis prevention.
- Microdevices for implants and living systems.
Dr. Evgeny Nesterov
Head of Nuclear Reactor Laboratory No 31
- Radiopharmaceuticals for diagnostics and therapy.
- Active pharmaceutical ingredients with α– and β– emitters for the targeted therapy of oncology and other diseases and for the development of radiopharmaceuticals.
- Medical products containing radioactive substances for the diagnostics and therapy of human diseases as well as for the rapid development of radiopharmaceuticals.